Top 10 Prescription Drugs That Damage Your Kidneys

The kidneys consist of a system for evacuating waste from the body through the production of urine. They also act as a blood filter and regulator of water in the body. Like any organ of the human body, the kidneys are affected by various factors including a few types of drugs. It is therefore important, before taking any medication, to seek the opinion of an expert to know the side effects.

The proper functioning of the kidneys is important to maintain a normal lifestyle, otherwise a dysfunction may cause kidney disease which is sometimes the origin of the definitive stoppage of renal function known as chronic renal failure.

Causes and symptoms of kidney disease

The causes of these kidney diseases can be very diverse:
  • Neglected or difficult to control hypertension
  • Type 2 diabetes (diabetic nephropathy)
  • Taking a drug that is toxic to the kidneys
  • Inflammatory disease
  • An inherited disease (eg polycystic disease)
  • Recurrent urinary lithiasis (kidney stones) with repeated urinary tract infections (pyelonephritis)
  • Heart failure (cardio-renal syndrome)

While the symptoms may vary according to the stage of the disease, the most frequent symptoms are as follows:
  • Fatigue and shortness of breath
  • Swelling of the feet
  • Respiratory difficulties
  • Hypertension difficult to treat
  • Inappetence, slimming
  • Digestive disorders (nausea, ...)

To detect the disease, a simple blood test may reveal an imbalance of the kidneys nevertheless a urinary analysis as well as a renal ultrasound are necessary to complete the diagnosis.

Renal insufficiency, whether advanced or not, shows no visible clinical signs. Most of the time, the disease is diagnosed by chance.

Stages of kidney disease:

Renal abnormalities: normal renal function but presence of blood in the urine.
Mild renal insufficiency: at this stage there are no or few symptoms, it is defined as a creatinine clearance of between 60 and 89 ml / min.

Moderate Renal Impairment: Presence and recurrence of symptoms such as fatigue, weight loss and foot edema. Other biological symptoms such as anemia as well as increased potassium and / or phosphorus levels in the blood.

Severe renal impairment: the symptoms of phase 3 are present or frequent.
End-stage renal insufficiency: at this stage the solutions are hemodialysis, peritoneal dialysis or transplantation.

Among the causes of the kidney diseases cited above, prolonged intake of some drugs. Here are the top 10 medications to remember:

1. Antibiotics: Several families or classes of antibiotics can harm the kidneys including meticillin, ciprofloxacin, vancomycin, sulphonamides.

2. Analgesics: The use of non-steroidal anti-inflammatory drugs (NSAIDs) may be accompanied by a temporary impairment of renal function, although it is rarely the cause of insufficiency kidney.

3. COX-2 Inhibitors: Like Celecoxib, these drugs have been created for the digestive tract but cause kidney damage.

4. Heartburn medications: Some of these medicines are based on lansoprasole, omeprazole, rabeprazole, esomeprazole and pantoprazole, which may affect kidney function.

5. Antiviral medications: Such as acyclovir (known as Zovirax) used for the treatment of herpes infections, and indinavir and tenofivir, used to treat HIV.
6. Medications to treat hypertension: Like captopril, uncontrolled hypertension is both a cause and a consequence of kidney failure.

7. Drugs for rheumatoid arthritis: Such as infliximab, chloroquine and hydrochloroquine, used to treat malaria and rheumatoid arthritis.

8. Lithium: This medication prescribed in case of depression or bipolar disorder can harm the kidneys

9. Anticonvulsants: Such as phenytoin and trimethadione, a prolonged intake of these medications used to treat convulsions and other conditions, can disrupt renal function.

10. Chemotherapy drugs such as pamidronate, interferons, carboplatin, cisplatin, tacrolimus, cyclosporine, mitomycin C, quinine, bevacizumab require careful monitoring because they are harmful to the kidneys.

Self-medication or taking medicines without medical consultation is dangerous, even without a prescription this requires precautions.

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